Mapping the neuroanatomic substrates of cognition in familial attention deficit hyperactivity disorder.

ABSTRACT:

Background

While the neuroanatomic substrates of symptoms of attention deficit hyperactivity disorder (ADHD) have been investigated, less is known about the neuroanatomic correlates of cognitive abilities pertinent to the disorder, particularly in adults. Here we define the neuroanatomic correlates of key cognitive abilities and determine if there are associations with histories of psychostimulant medication.

Methods

We acquired neuroanatomic magnetic resonance imaging data from 264 members of 60 families (mean age 29.5; s.d. 18.4, 116 with ADHD). Using linear mixed model regression, we tested for associations between cognitive abilities (working memory, information processing, intelligence, and attention), symptoms and both cortical and subcortical volumes.

Results

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SUBMITTER: Muster R 

PROVIDER: S-EPMC6252155 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature