Adenosine A₁-Dopamine D₁ Receptor Heteromers Control the Excitability of the Spinal Motoneuron.

ABSTRACT: While the role of the ascending dopaminergic system in brain function and dysfunction has been a subject of extensive research, the role of the descending dopaminergic system in spinal cord function and dysfunction is just beginning to be understood. Adenosine plays a key role in the inhibitory control of the ascending dopaminergic system, largely dependent on functional complexes of specific subtypes of adenosine and dopamine receptors. Combining a selective destabilizing peptide strategy with a proximity ligation assay and patch-clamp electrophysiology in slices from male mouse lumbar spinal cord, the present study demonstrates the existence of adenosine A₁-dopamine D₁ receptor heteromers in the spinal motoneuron by which adenosine tonically inhibits D₁ r

SUBMITTER: Rivera-Oliver M 

PROVIDER: S-EPMC6252157 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature