Constitutive plasma membrane monoamine transporter (PMAT, Slc29a4) deficiency subtly affects anxiety-like and coping behaviours.

ABSTRACT: Originally, uptake-mediated termination of monoamine (e.g., serotonin and dopamine) signalling was believed to only occur via high-affinity, low-capacity transporters ("uptake₁ ") such as the serotonin or dopamine transporters, respectively. Now, the important contribution of a second low-affinity, high-capacity class of biogenic amine transporters has been recognised, particularly in circumstances when uptake₁ transporter function is reduced (e.g., antidepressant treatment). Pharmacologic or genetic reductions in uptake₁ function can change locomotor, anxiety-like or stress-coping behaviours. Comparable behavioural investigations into reduced low-affinity, high-capacity transporter function are lacking, in part, due to a current dearth of drugs that select

SUBMITTER: Gilman TL 

PROVIDER: S-EPMC6252160 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature