African American Living Donors' Attitudes About APOL1 Genetic Testing: A Mixed Methods Study.

ABSTRACT:

Rationale & objective

African American live kidney donors ("donors") have a greater risk for kidney failure than European American donors. Apolipoprotein L1 gene (APOL1) variants in African Americans may be associated with this disparity.

Study design

Cross-sectional mixed-methods design.

Setting & participants

African American donors at 1 transplantation center.

Analytical approach

Semistructured interviews assessed attitudes about APOL1 genetic testing, willingness to undergo APOL1 testing, hypothetical decisions about donating with 2 APOL1 variants, and demographics. Surveys assessed perceptions of ethnic identity and genetics knowledge. Interview transcriptions were analyzed using thematic analysis. Survey data were analyzed using descriptive statistics.

SUBMITTER: Gordon EJ 

PROVIDER: S-EPMC6252162 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature