Chemical exchange rotation transfer (CERT) on human brain at 3 Tesla.

ABSTRACT:

Purpose

To test the ability of a novel pulse sequence applied in vivo at 3 Tesla to separate the contributions to the water signal from amide proton transfer (APT) and relayed nuclear Overhauser enhancement (rNOE) from background direct water saturation and semisolid magnetization transfer (MT). The lack of such signal source isolation has confounded conventional chemical exchange saturation transfer (CEST) imaging.

Methods

We quantified APT and rNOE signals using a chemical exchange rotation transfer (CERT) metric, MTR_double . A range of duty cycles and average irradiation powers were applied, and results were compared with conventional CEST analyses using asymmetry (MTR_asym ) and extrapolated magnetization transfer (EMR).

Results

Our results in

SUBMITTER: Lin EC 

PROVIDER: S-EPMC6252284 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature