1947. Influenza Vaccination via Oral Tablet is Protective and Induces a Unique Mucosal Immune Response

ABSTRACT: Abstract

Background

Oral vaccines delivered as tablets offer several advantages over traditional injection-based vaccines including ease of distribution and administration as well as temperature-stable formulation options. Oral vaccination is also advantageous because it directly induces a strong mucosal response, which is thought to be critical for preventing future infections. Here we present results from a phase II clinical challenge study comparing efficacy of an oral recombinant adenovirus-based vaccine expressing hemagluttinin (HA) from A/California 04/09 to that of a commercial injectable quadrivalent (QIV) influenza vaccine.

Methods

In this 2016–2017 clinical trial (NCT02918006), subjects were immunized with either oral vaccine, QIV, or placebo and then challenged

SUBMITTER: Kolhatkar N 

PROVIDER: S-EPMC6253129 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature