Simultaneous nitrosylation and N-nitrosation of a Ni-thiolate model complex of Ni-containing SOD.

ABSTRACT: Nitric oxide (NO) is used as a substrate analogue/spectroscopic probe of metal sites that bind and activate oxygen and its derivatives. To assess the interaction of superoxide with the Ni center in Ni-containing superoxide dismutase (NiSOD), we studied the reaction of NO⁺ and NO with the model complex, Et₄N[Ni(nmp)(SPh-o-NH₂-p-CF₃)] (1; nmp^2- = dianion of N-(2-mercaptoethyl)picolinamide; ^-SPh-o-NH₂-p-CF₃ = 2-amino-4-(trifluoromethyl)benzenethiolate) and its oxidized analogue 1^ox , respectively. The ultimate products of these reactions are the disulfide of ^-SPh-o-NH₂-p-CF₃ and the S,S-

SUBMITTER: Truong PT 

PROVIDER: S-EPMC6253683 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature