The GTPase BipA expressed at low temperature in Escherichia coli assists ribosome assembly and has chaperone-like activity.

ABSTRACT: BPI-inducible protein A (BipA) is a conserved ribosome-associated GTPase in bacteria that is structurally similar to other GTPases associated with protein translation, including IF2, EF-Tu, and EF-G. Its binding site on the ribosome appears to overlap those of these translational GTPases. Mutations in the bipA gene cause a variety of phenotypes, including cold and antibiotics sensitivities and decreased pathogenicity, implying that BipA may participate in diverse cellular processes by regulating translation. According to recent studies, a bipA-deletion strain of Escherichia coli displays a ribosome assembly defect at low temperature, suggesting that BipA might be involved in ribosome assembly. To further investigate BipA's role in ribosome biogenesis, here, we compared

SUBMITTER: Choi E 

PROVIDER: S-EPMC6254333 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature