Associations of lifestyle and vascular risk factors with Alzheimer's brain biomarker changes during middle age: a 3-year longitudinal study in the broader New York City area.

ABSTRACT:

Objective

To investigate the associations between lifestyle and vascular risk factors and changes in Alzheimer's disease (AD) biomarkers (beta-amyloid load via ¹¹C-PiB PET, glucose metabolism via ¹⁸F-FDG PET and neurodegeneration via structural MRI) and global cognition in middle-aged asymptomatic participants at risk for AD.

Design

Prospective, longitudinal.

Setting

The study was conducted at New York University Langone/Weill Cornell Medical Centres in New York City.

Participants

Seventy cognitively normal participants from multiple community sources, aged 30-60 years with lifestyle measures (diet, intellectual activity and physical activity), vascular risk measures and two imaging biomarkers visits over at least 2 years, were included in

SUBMITTER: Walters MJ 

PROVIDER: S-EPMC6254410 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature