Effective Targeting of TAG72⁺ Peritoneal Ovarian Tumors via Regional Delivery of CAR-Engineered T Cells.

ABSTRACT: Impressive clinical efficacy of chimeric antigen receptor (CAR)-engineered T cell therapy for hematological malignancies have prompted significant efforts in achieving similar responses in solid tumors. The lack of truly restricted and uniform expression of tumor-associated antigens, as well as limited T cell persistence and/or tumor trafficking pose major challenges for successful translation of CAR T cell therapy in solid tumors. Recent studies have demonstrated that aberrantly glycosylated cell surface proteins on tumor cells are amenable CAR targets. Tumor-associated glycoprotein 72 (TAG72) antigen is the sialyl-Tn found on multiple O-glycoproteins expressed at high levels on the surface of several cancer types, including ovarian cancer. Here, we developed a humanized TAG72-specific CA

SUBMITTER: Murad JP 

PROVIDER: S-EPMC6254427 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature