Role of Prenatal Hypoxia in Brain Development, Cognitive Functions, and Neurodegeneration.

ABSTRACT: This review focuses on the role of prenatal hypoxia in the development of brain functions in the postnatal period and subsequent increased risk of neurodegenerative disorders in later life. Accumulating evidence suggests that prenatal hypoxia in critical periods of brain formation results in significant changes in development of cognitive functions at various stages of postnatal life which correlate with morphological changes in brain structures involved in learning and memory. Prenatal hypoxia also leads to a decrease in brain adaptive potential and plasticity due to the disturbance in the process of formation of new contacts between cells and propagation of neuronal stimuli, especially in the cortex and hippocampus. On the other hand, prenatal hypoxia has a significant impact on expressi

SUBMITTER: Nalivaeva NN 

PROVIDER: S-EPMC6254649 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature