Platelets enhance the ability of bone-marrow mesenchymal stem cells to promote cancer metastasis.

ABSTRACT:

Background

Bone marrow-derived mesenchymal stem cells (BM-MSCs) have been identified to be closely associated with cancer progression. Our previous experimental results showed that BM-MSCs promote tumor growth and metastasis of gastric cancer through paracrine-soluble cytokines or exosomes. However, the elements that affect the role of BM-MSCs in promoting tumor metastasis are not clear. It is known that thrombocytosis in cancer patients is very common. Recently, platelets are recognized to play a critical role in tumor progression.

Purpose

This study aims to observe the effect of BM-MSCs which were co-cultured with platelets on tumor cell metastasis.

Methods

Platelet aggregation rate and the expression of P-selectin of platelets co-incubated with conditioned medium o

SUBMITTER: Wang Q 

PROVIDER: S-EPMC6254656 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature