Loss of miR-198 and -206 during primary tumor progression enables metastatic dissemination in human osteosarcoma.

ABSTRACT: The metastatic dissemination is a complex multistep process by which tumor cells from a primary site enter into the systemic circulation to finally spread at distant sites. Even if this mechanism is rare at the tumor level, it remains the major cause of Osteosarcoma-patients' relapse and mortality. MicroRNAs (miRNAs) have recently been described as novel epigenetics' genes' expression regulators actively implicated in cancer progression and dissemination. The understanding of their implication in the metastatic spreading could help clinicians to improve the outcome of osteosarcoma. We established the miRNA's expression-profile between primary bone-tumors (PTs), circulating tumor cells (CTCs) and lung metastatic (META) samples from in vivo mice xenograft models. Our results show that

SUBMITTER: Georges S 

PROVIDER: S-EPMC6254661 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature