Electrospun nanofiber blend with improved mechanical and biological performance.

ABSTRACT:

Background

Here, electrospun fibers based on a blend of polycaprolactone (PCL), poly(ethylene glycol) (PEG), and gelatin methacryloyl (GelMA) were developed. The careful choice of this polymer combination allowed for the preparation of a biomaterial that preserved the mechanical strength of PCL, while at the same time improving the hydrophilicity of the blended material and human osteoblast maturation.

Methods

The morphology, chemical structure, wettability, and mechanical properties before and after UV photocrosslinking were evaluated. Furthermore, human osteoblasts (hFOB) were cultivated for up to 21 days on the scaffolds, and their potential to upregulate cell proliferation, alkaline phosphatase (ALP) activity, and calcium deposition were investigated.

Results

Cont

SUBMITTER: Lobo AO 

PROVIDER: S-EPMC6255114 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature