Evolution of drug resistance in an antifungal-naive chronic Candida lusitaniae infection.

ABSTRACT: Management of the limited number of antimicrobials currently available requires the identification of infections that contain drug-resistant isolates and the discovery of factors that promote the evolution of drug resistance. Here, we report a single fungal infection in which we have identified numerous subpopulations that differ in their alleles of a single gene that impacts drug resistance. The diversity at this locus was markedly greater than the reported heterogeneity of alleles conferring antibiotic resistance in bacterial infections. Analysis of genomes from hundreds of Clavispora (Candida) lusitaniae isolates, through individual and pooled isolate sequencing, from a single individual with cystic fibrosis revealed at least 25 nonsynonymous mutations in MRR1

SUBMITTER: Demers EG 

PROVIDER: S-EPMC6255150 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature