Contactin-1/F3 Regulates Neuronal Migration and Morphogenesis Through Modulating RhoA Activity.

ABSTRACT: During neocortical development, newborn neurons migrate along radial fibers from the germinal ventricular zone (VZ) toward the cortical plate (CP) to populate the cerebral cortex. This radial migration requires adhesion activities between neurons and radial fibers; however, past research has identified only a limited number of adhesion molecules involved in this process. Contactin-1/F3 (Cntn1), a cell adhesion molecule expressed in the developing nervous system is essential for many key developmental events including neural cell adhesion, neurite outgrowth, axon guidance and myelination. However, the potential role of Cntn1 in neuronal migration during cortical development has not been investigated. Here we used in utero electroporation to introduce short hairpin RNA (shRNA) to knoc

SUBMITTER: Chen YA 

PROVIDER: S-EPMC6255823 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature