Iron homeostasis in Mycobacterium tuberculosis is essential for persistence.

ABSTRACT: Tuberculosis, caused by the obligate intracellular pathogen Mycobacterium tuberculosis (Mtb), is responsible for 2-3 million deaths annually worldwide. Intracellular adaptability, which is critical for long-term persistence, requires the pathogen to neutralize host-mediated insults. The iron-sulphur (Fe-S) cofactor is essential for many enzymes critical for such 'adaptation'. The Mtb genome harbors only one putative iron-sulphur cluster (ISC) operon (rv1460-66) predicted to be involved in the generation of the Fe-S cofactor. Except for rv1460, all other genes in this operon are anticipated to be essential. The current study investigated the role of rv1460, an sufR homologue of Mtb (sufR_TB), in maintaining intracellular Fe homeostasis and its implications on mycobacterial pathoge

SUBMITTER: Pandey M 

PROVIDER: S-EPMC6255865 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature