Zinc finger protein 32 promotes breast cancer stem cell-like properties through directly promoting GPER transcription.

ABSTRACT: Breast cancer is one of the leading causes of death in women. Due to the existence of a small fraction of stem cell-like subpopulations, some breast cancer subtypes exhibit very high malignancy and resistance to multiple therapies. The underlying mechanisms of how these subtypes acquire stem cell-like properties and progress more aggressively remain largely unknown. Zinc finger protein 32 (ZNF32), a newly discovered transcription factor, has been reported to be associated with breast cancer progression. However, many questions remain about its target genes and its exact mechanisms in regulating stem cell-like properties and drug resistance. In the present study, we examined the relationship between ZNF32 and GPER, a membrane-associated estrogen receptor, and we addressed their roles in ste

SUBMITTER: Li Y 

PROVIDER: S-EPMC6255875 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature