Iron removal enhances vitamin C-induced apoptosis and growth inhibition of K-562 leukemic cells.

ABSTRACT: Although vitamin C (VC) has recently garnered interest as an alternative cancer therapy, its clinical effects remain controversial. It was recently reported using in vitro prostate cancer cell lines that excess extracellular iron (EEI) diminishes anti-cancer effects of VC, promoting the decomposition of hydrogen peroxide (H₂O₂) generated by VC. Here we demonstrated that EEI diminished the inhibitory effect of VC on the survival of K562 human leukemic cells in vitro, by reducing the amount of H₂O₂ and abrogating the apoptosis pathways induced by VC. In vivo, in the presence of EEI, the growth inhibitory effect of VC on K562 cells was completely abrogated; in fact, VC enhanced K562 cell growth. Reduction of EEI restored the apoptosis-inducing effec

SUBMITTER: Tsuma-Kaneko M 

PROVIDER: S-EPMC6255900 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature