DNA methylation dynamics during embryonic development and postnatal maturation of the mouse auditory sensory epithelium.

ABSTRACT: The inner ear is a complex structure responsible for hearing and balance, and organ pathology is associated with deafness and balance disorders. To evaluate the role of epigenomic dynamics, we performed whole genome bisulfite sequencing at key time points during the development and maturation of the mouse inner ear sensory epithelium (SE). Our single-nucleotide resolution maps revealed variations in both general characteristics and dynamics of DNA methylation over time. This allowed us to predict the location of non-coding regulatory regions and to identify several novel candidate regulatory factors, such as Bach2, that connect stage-specific regulatory elements to molecular features that drive the development and maturation of the SE. Constructing in silico regulatory networks around site

SUBMITTER: Yizhar-Barnea O 

PROVIDER: S-EPMC6255903 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature