Epitope Specific Antibodies and T Cell Receptors in the Immune Epitope Database.

ABSTRACT: The Immune Epitope Database (IEDB) is a free public resource which catalogs experiments characterizing immune epitopes. To accommodate data from next generation repertoire sequencing experiments, we recently updated how we capture and query epitope specific antibodies and T cell receptors. Specifically, we are now storing partial receptor sequences sufficient to determine CDRs and VDJ gene usage which are commonly identified by repertoire sequencing. For previously captured full length receptor sequencing data, we have calculated the corresponding CDR sequences and gene usage information using IMGT numbering and VDJ gene nomenclature format. To integrate information from receptors defined at different levels of resolution, we grouped receptors based on their host species, receptor type and

SUBMITTER: Mahajan S 

PROVIDER: S-EPMC6255941 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature