Decavanadate Inhibits Mycobacterial Growth More Potently Than Other Oxovanadates.

ABSTRACT: ⁵¹V NMR spectroscopy is used to document, using speciation analysis, that one oxometalate is a more potent growth inhibitor of two Mycobacterial strains than other oxovanadates, thus demonstrating selectivity in its interaction with cells. Historically, oxometalates have had many applications in biological and medical studies, including study of the phase-problem in X-ray crystallography of the ribosome. The effect of different vanadate salts on the growth of Mycobacterium smegmatis (M. smeg) and Mycobacterium tuberculosis (M. tb) was investigated, and speciation was found to be critical for the observed growth inhibition. Specifically, the large orange-colored sodium decavanadate (V₁₀ O286- ) anion was found to be a stronger inhibitor of g

SUBMITTER: Samart N 

PROVIDER: S-EPMC6255961 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature