Evidence of a Causal Relationship Between Smoking Tobacco and Schizophrenia Spectrum Disorders.

ABSTRACT: There has been emerging evidence of an association between tobacco smoking and schizophrenia spectrum disorders (SSD). Two meta-analyses have reported that people who smoke tobacco have an ~2-fold increased risk of incident schizophrenia or psychosis, even after adjusting for confounding factors. This study aimed to critically appraise the research which has examined the association between tobacco smoking and SSD against the Bradford Hill criteria for causality, to determine the strength of the evidence for a causal relationship. Eight longitudinal studies (seven cohort studies and one case control study) were identified which examined tobacco smoking as an exposure and psychosis as an outcome. All seven cohort studies were assessed as being of high quality using the Newcastle-Ottawa Scal

SUBMITTER: Scott JG 

PROVIDER: S-EPMC6255982 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature