Evaluation of the adequacy of drug prescriptions in patients with chronic kidney disease: results from the CKD-REIN cohort.

ABSTRACT:

Aims

Drug prescription is difficult to manage in patients with chronic kidney disease (CKD). We assessed the prevalence and determinants of inappropriate drug prescriptions (whether contraindications or inappropriately high doses) with regard to kidney function in patients with CKD under nephrology care. We also assessed the impact of the equation used to estimate GFR on the prevalence estimates.

Methods

The CKD-REIN cohort includes 3033 outpatients with CKD (eGFR between 15 and 60 ml min^-1  1.73 m^-2 ). We examined the daily doses of pharmacological agents prescribed at study entry. Inappropriate prescription was defined as the reported prescription of either a contraindicated drug or an indicated drug at an inappropriately high dose level with regard t

SUBMITTER: Laville SM 

PROVIDER: S-EPMC6255993 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature