A Systematic Review of Medication Adherence Thresholds Dependent of Clinical Outcomes.

ABSTRACT: Background: In pharmacotherapy, the achievement of a target clinical outcome requires a certain level of medication intake or adherence. Based on Haynes's early empirical definition of sufficient adherence to antihypertensive medications as taking ≥80% of medication, many researchers used this threshold to distinguish adherent from non-adherent patients. However, we propose that different diseases, medications and patient's characteristics influence the cut-off point of the adherence rate above which the clinical outcome is satisfactory (thereafter medication adherence threshold). Moreover, the assessment of adherence and clinical outcomes may differ greatly and should be taken into consideration. To our knowledge, very few studies have defined adherence rates linked to clinical out

SUBMITTER: Baumgartner PC 

PROVIDER: S-EPMC6256123 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature