The Peripheral Inflammatory Response to Alpha-Synuclein and Endotoxin in Parkinson's Disease.

ABSTRACT: The immune system is activated in Parkinson's Disease (PD), as evidenced by neuroinflammatory changes within the brain as well as elevated immune markers in peripheral blood. Furthermore, inflammatory cytokine levels in the blood are associated with disease severity and rate of progression. However, the factors driving this immune response in PD are not well established. We investigated cell-extrinsic factors in systemic immune activation by using α-synuclein monomers and fibrils, as well as bacterial toxins, to stimulate peripheral blood mononuclear cells (PBMCs) derived from 31 patients and age/gender-matched controls. α-synuclein monomers or fibrils resulted in a robust cytokine response (as measured by supernatant cytokine concentrations and mRNA expression in cultured cells) in both P

SUBMITTER: White AJ 

PROVIDER: S-EPMC6256248 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature