Co-exposure subacute toxicity of silica nanoparticles and lead acetate on cardiovascular system.

ABSTRACT:

Background

The harmful effects following the release of nanomaterials into environment are of great concern today.

Purpose

In this study, subacute effect due to co-exposure to low-dose silica nanoparticles (SiNPs) and lead acetate (Pb) on cardiovascular system was detected in Sprague Dawley male rats.

Materials and methods

Histopathological and ultrastructural changes of heart, aortic arch and abdominal aorta were detected. Blood routine and blood biochemistry examinations were used to show the changes of blood components. The fibrinolytic and plasmin factors, inflammation-related factors and myocardial-related enzyme in serum were analysised by ELISA and Western blot assay.

Results

Histopathological and ultrastructural examination of heart, aortic arch, and ab

SUBMITTER: Feng L 

PROVIDER: S-EPMC6257131 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature