Photoactivatable Cell-Selective Dinuclear trans-Diazidoplatinum(IV) Anticancer Prodrugs.

ABSTRACT: A series of dinuclear octahedral Pt^IV complexes trans, trans, trans-[{Pt(N₃)₂(py)₂(OH)(OC(O)CH₂CH₂C(O)NH)}₂R] containing pyridine (py) and bridging dicarboxylate [R = -CH₂CH₂- (1), trans-1,2-C₆H₁₀- (2), p-C₆H₄- (3), -CH₂CH₂CH₂CH₂- (4)] ligands have been synthesized and characterized, including the X-ray crystal structures of complexes 1·2MeOH and 4, the first photoactivatable dinuclear Pt^IV complexes with azido ligands. The complexes are highly stable in the dark, but upon photoactivation with blue light (420 nm), they release the bridging ligand and mononuclear photoproducts. Upon irradiation w

SUBMITTER: Shi H 

PROVIDER: S-EPMC6257630 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature