ESCO2 inhibits tumor metastasis via transcriptionally repressing MMP2 in colorectal cancer.

ABSTRACT:

Background

Establishment of cohesion 1 homolog 2 (ESCO2) plays important roles in the regulation of cohesion and genomic stability and has been implicated in human cancers. Yet, its clinical significance and biological function in colorectal cancer (CRC) are unknown.

Methods

The expression of ESCO2 was examined by quantitative real-time PCR, Western blot, and immunohistochemistry. The role of ESCO2 in the tumor metastasis of CRC and the related mechanisms were investigated using in vitro and in vivo models.

Results

In this study, we show that low expression of ESCO2 in CRC was closely correlated with lymphatic and distant metastasis. Patients with low ESCO2 expression experienced shorter overall survival and disease-free survival in two independent cohorts containing

SUBMITTER: Guo XB 

PROVIDER: S-EPMC6257866 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature