Impact of Mitochondrial Fatty Acid Synthesis on Mitochondrial Biogenesis.

ABSTRACT: Biology students today are taught that mitochondria are 'the powerhouse of the cell'. This gross over-simplification of their cellular role has arguably led to a paucity of knowledge concerning the many other tasks carried out by this multifunctional organelle. Mitochondrial fatty acid synthesis (mtFAS) is one such under-appreciated pathway that is crucial for mitochondrial function, although even mitochondrial experts are often surprised to learn of its existence. For many years, the only function of mtFAS was thought to be the production of lipoic acid, an important co-factor for several mitochondrial enzymes. However, recent advances have revealed a far wider role for mtFAS in mitochondrial physiology. The discovery of human patients with mutations in mtFAS enzymes has brought renewed i

SUBMITTER: Nowinski SM 

PROVIDER: S-EPMC6258005 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature