Repeated Antigen Exposure Extends the Durability of Influenza-Specific Lung-Resident Memory CD8⁺ T Cells and Heterosubtypic Immunity.

ABSTRACT: Lung-resident primary memory CD8⁺ T cell populations (T_rm) induced by a single influenza infection decline within months, rendering the host susceptible to new heterosubtypic influenza infections. Here, we demonstrate that, relative to single virus exposure, repeated antigen exposure dramatically alters the dynamics of influenza-specific lung T_rm populations. Lung T_rm derived from repeatedly stimulated circulating memory CD8⁺ T cells exhibit extended durability and protective heterosubtypic immunity relative to primary lung T_rm. Parabiosis studies reveal that the enhanced durability of lung T_rm after multiple antigen encounters resulted from the generation of long-lasting circulating effector memory (T_em

SUBMITTER: Van Braeckel-Budimir N 

PROVIDER: S-EPMC6258017 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature