Long-Pulse Gastric Electrical Stimulation Repairs Interstitial Cells of Cajal and Smooth Muscle Cells in the Gastric Antrum of Diabetic Rats.

ABSTRACT:

Background/aims

The damage of interstitial cells of Cajal and smooth muscle cells has far-reaching implications in the pathogenesis of gastroparesis in diabetic patients. Gastric electrical stimulation (GES) is an efficient therapy for gastric motility disorders, but the mechanisms of GES require clarification.

Methods

Male rats were randomly divided into the control group, diabetic rat group (DM), diabetic rats with sham GES group (DM + SGES), and diabetic rats with different frequency GES group (DM + GES) (GES1: 5.5 cpm, 100 ms, 4 mA; GES2: 5.5 cpm, 300 ms, 4 mA; and GES3: 5.5 cpm, 550 ms, 2 mA). Gastric contractions were explored using the organ bath technique. The alterations of interstitial cells of Cajal, the SCF/c-kit pathway, and smooth muscle cells were also investi

SUBMITTER: Chen Y 

PROVIDER: S-EPMC6258098 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature