Long-term survival and swallowing outcomes in advanced stage oropharyngeal squamous cell carcinomas.

ABSTRACT:

Background

There is a paucity of studies reporting long-term survival outcomes for HPV/p16 positive oropharyngeal squamous cell carcinoma (OPSCC). This study aims to compare long-term outcomes of advanced stage p16 positive and negative OPSCCs, treated by surgical and non-surgical modalities.

Methods

OPSCC patients from 1998 to 2012 were identified through a prospectively collected cancer registry. P16 immunohistochemistry was used as a surrogate marker for HPV-OPSCC. Overall survival (OS) and aspiration free survival (AFS) comparisons were made between patients treated with chemoradiation (CRT) versus primary surgery and radiation/chemoradiation (S+RT/CRT) at 5, 10 and 15 years post-treatment.

Results

A total of 319 patients were included. P16 positive patients and n

SUBMITTER: Clark JM 

PROVIDER: S-EPMC6258135 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature