Do 2-year changes in superior frontal gyrus and global brain atrophy affect cognition?

ABSTRACT:

Introduction

Metabolic alterations to the superior frontal gyrus (SFG) have been linked to cognitive decline. Whether these indicate structural atrophy, which could be screened for at a larger scale using noninvasive structural imaging, is unknown.

Methods

We assessed annual structural magnetic resonance imaging scans and cognitive data from 3 consecutive years from 204 participants from the AD Neuroimaging Initiative database (mean age 72.24 [8.175] years). We evaluated associations between brain structural changes and performance in the Montreal Cognitive Assessment, Everyday Cognition Visuospatial subtest (ECog Visuospatial), and Functional Assessment Questionnaire.

Results

Changes in the surface area of the SFG were associated with changes in the outcome of the EC

SUBMITTER: Valdes Hernandez MDC 

PROVIDER: S-EPMC6258225 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature