Factors Associated With Graft Rejection in the Cornea Preservation Time Study.

ABSTRACT:

Purpose

To identify factors related to graft rejection following Descemet stripping automated endothelial keratoplasty (DSAEK) in the Cornea Preservation Time Study (CPTS).

Design

Cohort study within a multicenter randomized clinical trial.

Methods

A total of 1330 eyes of 1090 subjects undergoing DSAEK were randomized to receive a donor cornea with preservation time (PT) of 0-7 days (n = 675) or 8-14 days (n = 655) and followed for 3 years. Central endothelial cell density (ECD) was determined by a central image analysis reading center. Multivariable Cox models adjusted for PT, recipient diagnosis, and surgeon effect were used to identify factors associated with rejection.

Results

Cumulative probability of definite graft rejection was 3.6% (99% confidence inter

SUBMITTER: Stulting RD 

PROVIDER: S-EPMC6258266 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature