Precision and accuracy of cross-sectional area measurements used to measure coronary endothelial function with spiral MRI.

ABSTRACT:

Purpose

Coronary endothelial function (CEF) reflects vascular health and conventional invasive CEF measures predict cardiovascular events. MRI can now noninvasively measure CEF by quantifying coronary artery cross-sectional area changes in response to isometric handgrip exercise, an endothelial-dependent stressor. Area changes (10 to 20% in healthy; 2 to -12% in impaired vessels) are only a few imaging voxels because of MRI's limited spatial resolution. Here, with numerical simulations and phantom studies, we test whether Fourier interpolation enables sub-pixel area measurement precision and determine the smallest detectable area change using spiral MRI.

Methods

In vivo coronary SNR with the currently used CEF protocol at 3T was measured in 7 subjects for subsequent in vitro

SUBMITTER: Schar M 

PROVIDER: S-EPMC6258280 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature