Influences of experimental parameters on chemical exchange saturation transfer (CEST) metrics of brain tumors using animal models at 4.7T.

ABSTRACT: PURPOSE:To investigate the dependence of magnetization transfer ratio asymmetry at 3.5 ppm (MTRasym (3.5 ppm)), quantitative amide proton transfer (APT# ), and nuclear Overhauser enhancement (NOE# ) signals or contrasts on experimental imaging parameters. METHODS:Modified Bloch equation-based simulations using 2-pool and 5-pool exchange models and in vivo rat brain tumor experiments at 4.7T were performed with varied RF saturation power levels, saturation lengths, and relaxation delays. The MTRasym (3.5 ppm), APT# , and NOE# contrasts between tumor and normal tissues were compared among different experimental parameters. RESULTS:The MTRasym (3.5 ppm) image contrasts between tumor and normal tissues initially increased with the RF saturation length, and the maxima occurred at 1.6-2 s under

SUBMITTER: Heo HY 

PROVIDER: S-EPMC6258283 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature