Rapid dynamic contrast-enhanced MRI for small animals at 7T using 3D ultra-short echo time and golden-angle radial sparse parallel MRI.

ABSTRACT:

Purpose

To develop a rapid dynamic contrast-enhanced MRI method with high spatial and temporal resolution for small-animal imaging at 7 Tesla.

Methods

An ultra-short echo time (UTE) pulse sequence using a 3D golden-angle radial sampling was implemented to achieve isotropic spatial resolution with flexible temporal resolution. Continuously acquired radial spokes were grouped into subsets for image reconstruction using a multicoil compressed sensing approach (Golden-angle RAdial Sparse Parallel; GRASP). The proposed 3D-UTE-GRASP method with high temporal and spatial resolutions was tested using 7 mice with GL261 intracranial glioma models.

Results

Iterative reconstruction with different temporal resolutions and regularization factors λ showed that, in all cases, the cos

SUBMITTER: Zhang J 

PROVIDER: S-EPMC6258350 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature