Does the melatonin receptor 1B gene polymorphism have a role in postoperative delirium?

ABSTRACT:

Introduction

Patients undergoing cardiac surgery are at high risk for postoperative delirium, which is associated with longer hospital and intensive care lengths of stays, increased morbidity and mortality. Because sleep disturbances are common in delirium, melatonin has been an area of interest in the treatment of delirium. The rs10830963 single nucleotide polymorphism of the melatonin receptor 1B gene can cause pathological dysfunction of this receptor and is associated with delayed morning offset of melatonin. We hypothesized patients undergoing aortic cardiac surgery who have the risk genotype of a melatonin receptor 1B polymorphism would have a higher incidence of postoperative delirium.

Methods

Ninety-eight patients undergoing aortic root or valve surgery underwent ana

SUBMITTER: Mahanna-Gabrielli E 

PROVIDER: S-EPMC6258533 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature