Genome-wide DNA methylation changes in CD19⁺ B cells from relapsing-remitting multiple sclerosis patients.

ABSTRACT: Multiple Sclerosis (MS) is an inflammatory and neurodegenerative disease of the central nervous system. The inflammatory process in MS is driven by both T and B cells and current therapies are targeted to each of these cell types. Epigenetic mechanisms may provide a valuable link between genes and environment. DNA methylation is the best studied epigenetic mechanism and is recognized as a potential contributor to MS risk. The objective of this study was to identify DNA methylation changes associated with MS in CD19⁺ B-cells. We performed an epigenome-wide association analysis of DNA methylation in the CD19⁺ B-cells from 24 patients with relapsing-remitting MS on various treatments and 24 healthy controls using Illumina 450 K arrays. A large differentially methylated r

SUBMITTER: Maltby VE 

PROVIDER: S-EPMC6258668 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature