Pd(OAc)₂-catalyzed asymmetric hydrogenation of sterically hindered N-tosylimines.

ABSTRACT: Asymmetric hydrogenation of sterically hindered substrates still constitutes a long-standing challenge in the area of asymmetric catalysis. Herein, an efficient palladium acetate (an inexpensive Pd salt with low toxicity) catalyzed asymmetric hydrogenation of sterically hindered N-tosylimines is realized with high catalytic activities (S/C up to 5000) and excellent enantioselectivities (ee up to 99.9%). Quantum chemical calculations suggest that uniformly high enantioselectivities are observed due to the structurally different S- and R-reaction pathways.

SUBMITTER: Chen J 

PROVIDER: S-EPMC6258694 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature