Cisplatin treatment induces attention deficits and impairs synaptic integrity in the prefrontal cortex in mice.

ABSTRACT: Patients treated for cancer frequently experience chemobrain, characterized by impaired memory and reduced attention. These deficits often persist after treatment, and no preventive or curative interventions exist. In mice, we assessed the effect of cisplatin chemotherapy on attention using the 5-choice serial reaction time task and on synaptic integrity. We also assessed the capacity of mesenchymal stem cells to normalize the characteristics of chemobrain. Mice were trained in the 5-choice serial reaction time task. After reaching advancement criteria at a 4-second stimulus time, they were treated with cisplatin followed by nasal administration of mesenchymal stem cells. Cisplatin reduced the percentage of correct responses due to an increase in omissions, indicating attention deficits. M

SUBMITTER: Huo X 

PROVIDER: S-EPMC6258730 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature