Celiac Disease: A Review of Current Concepts in Pathogenesis, Prevention, and Novel Therapies.

ABSTRACT: Our understanding of celiac disease and how it develops has evolved significantly over the last half century. Although traditionally viewed as a pediatric illness characterized by malabsorption, it is now better seen as an immune illness with systemic manifestations affecting all ages. Population studies reveal this global disease is common and, in many countries, increasing in prevalence. These studies underscore the importance of specific HLA susceptibility genes and gluten consumption in disease development and suggest that other genetic and environmental factors could also play a role. The emerging data on viral and bacterial microbe-host interactions and their alterations in celiac disease provides a plausible mechanism linking environmental risk and disease development. Although the

SUBMITTER: Tye-Din JA 

PROVIDER: S-EPMC6258800 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature