Morin Protects Channel Catfish From Aeromonas hydrophila Infection by Blocking Aerolysin Activity.

ABSTRACT: Aeromonas hydrophila (A. hydrophila) is an opportunistic bacterial pathogen widely distributed in the environments, particular aquatic environment. The pathogen can cause a range of infections in both human and animals including fishes. However, the application of antibiotics in treatment of A. hydrophila infections leads to the emergence of resistant strains. Consequently, new approaches need to be developed in fighting this pathogen. Aerolysin, the chief virulence factor produced by pathogenic A. hydrophila strains has been employed as target identifying new drugs. In our present study, we found that morin, a flavonoid without anti-bacterial activity isolated from traditional Chinese medicine, could directly inhibit the hemolytic activity of aerolysin. To dete

SUBMITTER: Dong J 

PROVIDER: S-EPMC6258893 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature