Combined anatomical optical coherence tomography and intraluminal pressure reveal viscoelasticity of the in vivo airway.

ABSTRACT: It is hypothesized that the local, viscoelastic (time-dependent) properties of the airway are important to accurately model and ultimately predict dynamic airway collapse in airway obstruction. Toward this end, we present a portable, endoscopic, swept-source anatomical optical coherence tomography (aOCT) system combined with a pressure catheter to capture local airway dynamics in vivo during respiration. aOCT scans were performed in the airways of a mechanically ventilated pig under paralysis with dynamic and static ventilation protocols. Validation of dynamic aOCT luminal cross-sectional area (CSA) measurements against Cine CT, obtained during the same exam, showed an aggregate difference of 15  %    ±  3  %  . aOCT-derived CSA obtained in the in vivo trachea also exhibited hysteresis as

SUBMITTER: Balakrishnan S 

PROVIDER: S-EPMC6259006 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature