Kinetic evaluation and test-retest reproducibility of [¹¹C]UCB-J, a novel radioligand for positron emission tomography imaging of synaptic vesicle glycoprotein 2A in humans.

ABSTRACT: Synaptic vesicle glycoprotein 2A (SV2A) is ubiquitously present in presynaptic terminals. Here we report kinetic modeling and test-retest reproducibility assessment of the SV2A positron emission tomography (PET) radioligand [¹¹C]UCB-J in humans. Five volunteers were examined twice on the HRRT after bolus injection of [¹¹C]UCB-J. Arterial blood samples were collected for measurements of radiometabolites and free fraction. Regional time-activity curves were analyzed with 1-tissue (1T) and 2-tissue (2T) compartment models to estimate volumes of distribution ( V_T). Parametric maps were generated using the 1T model. [¹¹C]UCB-J metabolized fairly quickly, with parent fraction of 36 ± 13% at 15 min after injection. Plasma free fraction was 32 ± 1%. Regi

SUBMITTER: Finnema SJ 

PROVIDER: S-EPMC6259313 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature