Transit time homogenization in ischemic stroke - A novel biomarker of penumbral microvascular failure?

ABSTRACT: Cerebral ischemia causes widespread capillary no-flow in animal studies. The extent of microvascular impairment in human stroke, however, is unclear. We examined how acute intra-voxel transit time characteristics and subsequent recanalization affect tissue outcome on follow-up MRI in a historic cohort of 126 acute ischemic stroke patients. Based on perfusion-weighted MRI data, we characterized voxel-wise transit times in terms of their mean transit time (MTT), standard deviation (capillary transit time heterogeneity - CTH), and the CTH:MTT ratio (relative transit time heterogeneity), which is expected to remain constant during changes in perfusion pressure in a microvasculature consisting of passive, compliant vessels. To aid data interpretation, we also developed a computational model tha

SUBMITTER: Engedal TS 

PROVIDER: S-EPMC6259320 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature