Recent advances in understanding the ryanodine receptor calcium release channels and their role in calcium signalling.

ABSTRACT: The ryanodine receptor calcium release channel is central to cytoplasmic Ca 2+ signalling in skeletal muscle, the heart, and many other tissues, including the central nervous system, lymphocytes, stomach, kidney, adrenal glands, ovaries, testes, thymus, and lungs. The ion channel protein is massive (more than 2.2 MDa) and has a structure that has defied detailed determination until recent developments in cryo-electron microscopy revealed much of its structure at near-atomic resolution. The availability of this high-resolution structure has provided the most significant advances in understanding the function of the ion channel in the past 30 years. We can now visualise the molecular environment of individual amino acid residues that form binding sites for essential modulators of ion channel

SUBMITTER: Dulhunty AF 

PROVIDER: S-EPMC6259491 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature