Effects of Delayed Cord Clamping on 4-Month Ferritin Levels, Brain Myelin Content, and Neurodevelopment: A Randomized Controlled Trial.

ABSTRACT:

Objective

To evaluate whether placental transfusion influences brain myelination at 4 months of age.

Study design

A partially blinded, randomized controlled trial was conducted at a level III maternity hospital in the US. Seventy-three healthy term pregnant women and their singleton fetuses were randomized to either delayed umbilical cord clamping (DCC, >5 minutes) or immediate clamping (ICC, <20 seconds). At 4 months of age, blood was drawn for ferritin levels. Neurodevelopmental testing (Mullen Scales of Early Learning) was administered, and brain myelin content was measured with magnetic resonance imaging. Correlations between myelin content and ferritin levels and group-wise DCC vs ICC brain myelin content were completed.

Results

In the DCC and ICC groups, clampin

SUBMITTER: Mercer JS 

PROVIDER: S-EPMC6259583 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature