Genomic and transcriptomic comparisons of closely related malaria parasites differing in virulence and sequestration pattern.

ABSTRACT: Background: Malaria parasite species differ greatly in the harm they do to humans. While P. falciparum kills hundreds of thousands per year, P. vivax kills much less often and P. malariae is relatively benign. Strains of the rodent malaria parasite Plasmodium chabaudi show phenotypic variation in virulence during infections of laboratory mice. This make it an excellent species to study genes which may be responsible for this trait. By understanding the mechanisms which underlie differences in virulence we can learn how parasites adapt to their hosts and how we might prevent disease. Methods: Here we present a complete reference genome sequence for a more virulent P. chabaudi strain, PcCB, and perform a detailed comparison with the genome of

SUBMITTER: Lin JW 

PROVIDER: S-EPMC6259598 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature